Vicinitas Therapeutics Launches With $65 Million in Series A Financing to Advance Precision Medicines to Stabilize Key Proteins to Treat Disease

Financing led by a16z and Deerfield Management with participation from Droia Ventures, GV, The Mark Foundation for Cancer Research and the Berkeley Catalyst Fund Exclusive license from academic-industry collaboration with UC Berkeley Professor Daniel Nomura for proprietary DUBTAC platform for targeted protein stabilization SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)– Vicinitas Therapeutics, a biotechnology company advancing a … Read more

‘New era in digital biology’: AI reveals structures of nearly all known proteins | Science

What a difference a year makes. Twelve months ago, the artificial intelligence (AI) company DeepMind stunned many scientists with the release of predicted structures for some 350,000 proteins, part of the work recognized as Science‘s 2021 Breakthrough of the Year. Yesterday, DeepMind and its partners went much, much further. The company unveiled the likely structures … Read more

How to Boost Muscle Cell Production of Gene Therapy Proteins

In a major new development in the quest to develop better gene therapies for different diseases, researchers at the University of Massachusetts (UMass) Amherst and UMass Chan Medical School have mapped—with what they claim is unprecedented clarity—the expression and maturation of alpha- 1 antitrypsin (AAT). The results, which detail the molecular folding of the AAT … Read more

Taste sensors keep proteins in order in flies

A set of genes that promote sweet taste sensation is also crucial for protein management during fly development, according to a new study by Eugenia Piddini of the University of Bristol, United Kingdom, and colleagues, publishing July 21st in the open-access journal PLOS Biology. The finding expands the understanding of a key process in successful … Read more

Study probes role of BET proteins in coronavirus infection

SAN FRANCISCO, CA — A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19. However, in a surprising study, scientists at Gladstone Institutes and UC San Francisco (UCSF) discovered that BET proteins are actually crucial for the body … Read more

New method for developing Pichia pastoris yeast strains with high productivity of useful proteins – BIOENGINEER.ORG

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (* 1) in order to increase its secretory production of useful proteins (* 2). Through a series of processes that involved combining gene disruptions and then serially cultivating (* 3) the … Read more

Plant-microbe biology study uncovers trigger for tumor growth in humans

Building on computational studies, the researchers found that mutating any one of four amino acids into the hepatocyte growth factor (HGF) protein, which is critical to the function of PAN, turned off a signaling pathway that is heightened in cancer cells. The study suggests selectively targeting the PAN domain may improve outcomes in … Read more

Measuring levels of proteins in eye fluid may accurately predict need for lifelong macular degeneration therapy – BIOENGINEER.ORG

In a study of eye fluid from 38 patients, Johns Hopkins Medicine researchers say they have found that levels of a specific protein appears to help accurately predict whether people with the wet form of age-related macular degeneration may need lifelong, frequent eye injections to preserve. vision or if they can be safely weaned off … Read more

PICASSO technique drives biological molecules into technicolor? The new imaging approach brings current imaging colors from four to more than 15 for mapping overlapping proteins — ScienceDaily

Pablo Picasso’s surreal cubist artistic style shifted common features into unrecognizable scenes, but a new imaging approach bearing his namesake may elucidate the most complicated subject: the brain. Employing artificial intelligence to clarify spectral color blending of tiny molecules used to stain specific proteins and other items of research interest, the PICASSO technique, allows researchers … Read more

Biochemists use proteins to change how neurons communicate

In a new study, scientists detail how they coaxed excitatory neurons to release neurotransmitters usually produced by inhibitory neurons. BUFFALO, NY – As you’re reading this sentence, cells in your brain are sending rapid-fire electrical signals between each other, transmitting information. They’re doing so via tiny, specialized junctions between them called synapses. Synapses lie between … Read more