Advanced imaging reveals mired migration of neurons in Rett syndrome lab

Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain tissue models of Rett syndrome, producing new insight into how developmental deficits observed in the brains of patients with the devastating disorder may emerge. Using … Read more

SARS-CoV-2 hijacks nanotubes between neurons to infect them

COVID-19 often leads to neurological symptoms, such as a loss of taste or smell, or cognitive impairments (including memory loss and concentration difficulties), both during the acute phase of the disease and over the long term with “long COVID” syndrome. But the way in which the infection reaches the brain was previously unknown. Scientists from … Read more

New findings reveal how neurons build and maintain their capacity to communicate

The nervous system works because neurons communicate across connections called synapses. They “talk” when calcium ions flow through channels into “active zones” that are loaded with vesicles carrying molecular messages. The electrically charged calcium causes vesicles to “fuse” to the outer membrane of presynaptic neurons, releasing their communicative chemical cargo to the postsynaptic cell. In … Read more

Discovery of molecular signatures of immature neurons in the human brain throughout life provide new insights into brain plasticity and other functions, according to Penn Medicine researchers

PHILADELPHIA – A team led by researchers at the Perelman School of Medicine at the University of Pennsylvania has used advanced techniques to show that, in a key memory region of the brain called the hippocampus, immature, plastic neurons are present in significant numbers throughout the human lifespan. The findings, published this month in Nature, … Read more

Malignant or benign? Quick and accurate diagnosis with artificial tactile neurons – BIOENGINEER.ORG

The stiffness levels and distributions of various biological materials reflect disease-related information, from cells to tissues. For example, malignant breast tumors are usually stiffer and have a more irregular shape than benign breast tumors. Ultrasound elastography can non-invasively determine the degree and shape of the tissue stiffness and is used for diagnosing breast cancer owing … Read more

Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner

Quote: Brites P, Sousa MM (2022) Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner. PLoS Biol 20 (7): e3001706. https://doi.org/10.1371/journal.pbio.3001706 Published: July 6, 2022 Copyright: © 2022 Brites, Sousa. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted … Read more

In Krabbe disease, neurons may bring about their own destruction – BIOENGINEER.ORG

The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study publishing July 5th in the open-access journal PLOS Biology by Daesung Shin of the University at Buffalo, US and colleagues. The discovery represents a new mechanism of action for the mutant … Read more

Aligning evidence for the genesis of visual gamma oscillations

Quote: Foster BL, Bartoli E (2022) Aligning evidence for the genesis of visual gamma oscillations. PLoS Biol 20 (6): e3001701. https://doi.org/10.1371/journal.pbio.3001701 Published: June 28, 2022 Copyright: © 2022 Foster, Bartoli. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any … Read more

The mechanisms regulating the balance between the formation of neurons and the maintenance of stem cells in the formation of the brain revealed

Anew study by the Neuronal Dynamics Research Group at UPF has elucidated the cellular and molecular mechanisms that regulate the balance between the differentiation of neurons and the maintenance of progenitor cells during the construction of the embryonic brain. The study, conducted in the zebrafish model, has been published in the journal Cell Reports. Anew … Read more

Neurons and glia collaborate to drive neural regeneration following brain injury – BIOENGINEER.ORG

One of the most devastating aspects of stroke and traumatic brain injury is that the neurons we lose are never replaced. This means that depending on the injury site, patients may suffer long-term impairments of crucial motor or cognitive functions, such as language and memory. Credit: Rhiner Lab, The Champalimaud Foundation. One of the most … Read more