BIRMINGHAM, Ala. – While lower vertebrates can repair their adult hearts after a heart attack, mammals – including humans – cannot. The ability to regenerate dead muscle tissue in mammalian hearts disappears just a few days after birth because the heart muscle cells, called cardiomyocytes, exit the cell cycle. BIRMINGHAM, Ala. – While lower vertebrates … Read more
The deletion of the Wt1 gene during the early stages of the embryonic reproductive organ formation leads to differences in sex development in adult mice, according to an article published in the journal PLOS Genetics and led by the lecturer Ofelia Martínez-Estrada, from the Faculty of Biology and the Biomedicine Research Institute (IRBio) of the … Read more
The deletion of the Wt1 gene during the early stages of the embryonic reproductive organ formation leads to differences in sex development in adult mice, according to an article published in the journal PLOS Genetics and led by the lecturer Ofelia Martínez-Estrada, from the Faculty of Biology and the Biomedicine Research Institute (IRBio) of the … Read more
Stem Cell and Gene Therapy Biological Testing Market Stem Cell and Gene Therapy Biological Testing Market Key Insights, Regional Analysis with Future Outlook PUNE, MAHARASHTRA, INDIA, June 22, 2022 /EINPresswire.com/ – Stem Cell and Gene Therapy Biological Testing Market report contains key data about the market, emerging trends, product usage, motivating factors for customers and … Read more
Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life. New research led by the University of Bath shows the mechanism by which genes coding for a subset of long non-coding RNA (lncRNA) interact with neighboring genes … Read more
Over the years, the domestication of grasses like wheat, rice, barley, and sorghum for consumption has resulted in certain modifications to their morphology. One such modification is the partial or complete elimination of the ‘awns’, which are the bristle- or needle-like appendages extending from the tip of the lemma in grass spikelets. The awn protects … Read more
Data for a new gene-function map are available for other scientists to use. “It’s a big resource in the way the human genome is a big resource, in that you can go in and do discovery-based research,” says Professor Jonathan Weissman. Scientists used their single-cell sequencing tool Perturb-seq on every expressed gene in the human … Read more
Whitehead Institute researchers have created the first information-rich genotype-phenotype map that reveals a multidimensional portrait of gene and cellular function. By performing genome-scale Perturb-seq (CRISPR-based screens with single-cell RNA-sequencing readouts) targeting all expressed genes in millions of human cells, Jonathan Weissman, PhD, and colleagues have mapped the transcriptional effects of genetic perturbations to predict the … Read more
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including Whitehead Institute, and was finally completed in 2003. Now, over two decades later, Whitehead Institute Member Jonathan Weissman and colleagues have gone beyond the sequence to present the … Read more
Credit: CC0 Public Domain The APOE4 gene is the most powerful genetic factor driving a person’s risk for developing late-onset Alzheimer’s disease. But scientists from Stanford Medicine have discovered a rare mutation that actually negates the Alzheimer’s risk posed by the APOE4 gene. They found the R251G variant changes just a single amino acid in … Read more